Description
A ferroptosis inhibitor; inhibits cell death induced by erastin (EC50 = 60 nM) and RSL3, but not by hydrogen peroxide, rotenone, or staurosporine, in HT-1080 cells at 0.5 µM; inhibits erastin-induced production of ROS and lipid peroxidation in HT-1080 cells at 0.5 µM; increases cell survival in cell-based models of Huntington’s disease, periventricular leukomalacia, and kidney proximal tubule damage; inhibits cell death induced by L-glutamate in a rat OHSC model at 2 µM; inhibits autooxidation of lipids by trapping peroxyl radicals`